                         SEQUENCE LISTING

<110>  Genzyme Corporation
       SCARIA, Abraham
       WHITE, Gary
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITING INTERLEUKIN PATHWAYS

<130>  0800-0051.40

<150>  US 60/974,892
<151>  2007-09-25

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  2601
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IL-17r

<400>  1
atgggggccg cacgcagccc gccgtccgct gtcccggggc ccctgctggg gctgctcctg       60

ctgctcctgg gcgtgctggc cccgggtggc gcctccctgc gactcctgga ccaccgggcg      120

ctggtctgct cccagccggg gctaaactgc acggtcaaga atagtacctg cctggatgac      180

agctggattc accctcgaaa cctgaccccc tcctccccaa aggacctgca gatccagctg      240

cactttgccc acacccaaca aggagacctg ttccccgtgg ctcacatcga atggacactg      300

cagacagacg ccagcatcct gtacctcgag ggtgcagagt tatctgtcct gcagctgaac      360

accaatgaac gtttgtgcgt caggtttgag tttctgtcca aactgaggca tcaccacagg      420

cggtggcgtt ttaccttcag ccactttgtg gttgaccctg accaggaata tgaggtgacc      480

gttcaccacc tgcccaagcc catccctgat ggggacccaa accaccagtc caagaatttc      540

cttgtgcctg actgtgagca cgccaggatg aaggtaacca cgccatgcat gagctcaggc      600

agcctgtggg accccaacat caccgtggag accctggagg cccaccagct gcgtgtgagc      660

ttcaccctgt ggaacgaatc tacccattac cagatcctgc tgaccagttt tccgcacatg      720

gagaaccaca gttgctttga gcacatgcac cacatacctg cgcccagacc agaagagttc      780

caccagcgat ccaacgtcac actcactcta cgcaacctta aagggtgctg tcgccaccaa      840

gtgcagatcc agcccttctt cagcagctgc ctcaatgact gcctcagaca ctccgcgact      900

gtttcctgcc cagaaatgcc agacactcca gaaccaattc cggactacat gcccctgtgg      960

gtgtactggt tcatcacggg catctccatc ctgctggtgg gctccgtcat cctgctcatc     1020

gtctgcatga cctggaggct agctgggcct ggaagtgaaa aatacagtga tgacaccaaa     1080

tacaccgatg gcctgcctgc ggctgacctg atccccccac cgctgaagcc caggaaggtc     1140

tggatcatct actcagccga ccaccccctc tacgtggacg tggtcctgaa attcgcccag     1200

ttcctgctca ccgcctgcgg cacggaagtg gccctggacc tgctggaaga gcaggccatc     1260

tcggaggcag gagtcatgac ctgggtgggc cgtcagaagc aggagatggt ggagagcaac     1320

tctaagatca tcgtcctgtg ctcccgcggc acgcgcgcca agtggcaggc gctcctgggc     1380

cggggggcgc ctgtgcggct gcgctgcgac cacggaaagc ccgtggggga cctgttcact     1440

gcagccatga acatgatcct cccggacttc aagaggccag cctgcttcgg cacctacgta     1500

gtctgctact tcagcgaggt cagctgtgac ggcgacgtcc ccgacctgtt cggcgcggcg     1560

ccgcggtacc cgctcatgga caggttcgag gaggtgtact tccgcatcca ggacctggag     1620

atgttccagc cgggccgcat gcaccgcgta ggggagctgt cgggggacaa ctacctgcgg     1680

agcccgggcg gcaggcagct ccgcgccgcc ctggacaggt tccgggactg gcaggtccgc     1740

tgtcccgact ggttcgaatg tgagaacctc tactcagcag atgaccagga tgccccgtcc     1800

ctggacgaag aggtgtttga ggagccactg ctgcctccgg gaaccggcat cgtgaagcgg     1860

gcgcccctgg tgcgcgagcc tggctcccag gcctgcctgg ccatagaccc gctggtcggg     1920

gaggaaggag gagcagcagt ggcaaagctg gaacctcacc tgcagccccg gggtcagcca     1980

gcgccgcagc ccctccacac cctggtgctc gccgcagagg agggggccct ggtggccgcg     2040

gtggagcctg ggcccctggc tgacggtgcc gcagtccggc tggcactggc gggggagggc     2100

gaggcctgcc cgctgctggg cagcccgggc gctgggcgaa atagcgtcct cttcctcccc     2160

gtggaccccg aggactcgcc ccttggcagc agcaccccca tggcgtctcc tgacctcctt     2220

ccagaggacg tgagggagca cctcgaaggc ttgatgctct cgctcttcga gcagagtctg     2280

agctgccagg cccagggggg ctgcagtaga cccgccatgg tcctcacaga cccacacacg     2340

ccctacgagg aggagcagcg gcagtcagtg cagtctgacc agggctacat ctccaggagc     2400

tccccgcagc cccccgaggg actcacggaa atggaggaag aggaggaaga ggagcaggac     2460

ccagggaagc cggccctgcc actctctccc gaggacctgg agagcctgag gagcctccag     2520

cggcagctgc ttttccgcca gctgcagaag aactcgggct gggacacgat ggggtcagag     2580

tcagaggggc ccagtgcatg a                                               2601


<210>  2
<211>  866
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IL-17r

<400>  2

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210>  3
<211>  1890
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IL-23r

<400>  3
atgaatcagg tcactattca atgggatgca gtaatagccc tttacatact cttcagctgg       60

tgtcatggag gaattacaaa tataaactgc tctggccaca tctgggtaga accagccaca      120

atttttaaga tgggtatgaa tatctctata tattgccaag cagcaattaa gaactgccaa      180

ccaaggaaac ttcattttta taaaaatggc atcaaagaaa gatttcaaat cacaaggatt      240

aataaaacaa cagctcggct ttggtataaa aactttctgg aaccacatgc ttctatgtac      300

tgcactgctg aatgtcccaa acattttcaa gagacactga tatgtggaaa agacatttct      360

tctggatatc cgccagatat tcctgatgaa gtaacctgtg tcatttatga atattcaggc      420

aacatgactt gcacctggaa tgctgggaag ctcacctaca tagacacaaa atacgtggta      480

catgtgaaga gtttagagac agaagaagag caacagtatc tcacctcaag ctatattaac      540

atctccactg attcattaca aggtggcaag aagtacttgg tttgggtcca agcagcaaac      600

gcactaggca tggaagagtc aaaacaactg caaattcacc tggatgatat agtgatacct      660

tctgcagccg tcatttccag ggctgagact ataaatgcta cagtgcccaa gaccataatt      720

tattgggata gtcaaacaac aattgaaaag gtttcctgtg aaatgagata caaggctaca      780

acaaaccaaa cttggaatgt taaagaattt gacaccaatt ttacatatgt gcaacagtca      840

gaattctact tggagccaaa cattaagtac gtatttcaag tgagatgtca agaaacaggc      900

aaaaggtact ggcagccttg gagttcactg ttttttcata aaacacctga aacagttccc      960

caggtcacat caaaagcatt ccaacatgac acatggaatt ctgggctaac agttgcttcc     1020

atctctacag ggcaccttac ttctgacaac agaggagaca ttggactttt attgggaatg     1080

atcgtctttg ctgttatgtt gtcaattctt tctttgattg ggatatttaa cagatcattc     1140

cgaactggga ttaaaagaag gatcttattg ttaataccaa agtggcttta tgaagatatt     1200

cctaatatga aaaacagcaa tgttgtgaaa atgctacagg aaaatagtga acttatgaat     1260

aataattcca gtgagcaggt cctatatgtt gatcccatga ttacagagat aaaagaaatc     1320

ttcatcccag aacacaagcc tacagactac aagaaggaga atacaggacc cctggagaca     1380

agagactacc cgcaaaactc gctattcgac aatactacag ttgtatatat tcctgatctc     1440

aacactggat ataaacccca aatttcaaat tttctgcctg agggaagcca tctcagcaat     1500

aataatgaaa ttacttcctt aacacttaaa ccaccagttg attccttaga ctcaggaaat     1560

aatcccaggt tacaaaagca tcctaatttt gctttttctg tttcaagtgt gaattcacta     1620

agcaacacaa tatttcttgg agaattaagc ctcatattaa atcaaggaga atgcagttct     1680

cctgacatac aaaactcagt agaggaggaa accaccatgc ttttggaaaa tgattcaccc     1740

agtgaaacta ttccagaaca gaccctgctt cctgatgaat ttgtctcctg tttggggatc     1800

gtgaatgagg agttgccatc tattaatact tattttccac aaaatatttt ggaaagccac     1860

ttcaatagga tttcactctt ggaaaagtag                                      1890


<210>  4
<211>  629
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IL-23r

<400>  4

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 


<210>  5
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct sIL23R-9gly-CH3

<400>  5
atgaatcatg tcactattca atgggatgca gtaatagccc tttacatact cttcagctgg       60

tgtcatggag gaattacaaa tataaactgc tctggccaca tctgggtaga accagccaca      120

atttttaaga tgggtatgaa tatctctata tattgccaag cagcaattaa gaactgccaa      180

ccaaggaaac ttcattttta taaaaatggc atcaaagaaa gatttcaaat cacaaggatt      240

aataaaacaa cagctcggct ttggtataaa aactttctgg aaccacatgc ttctatgtac      300

tgcactgctg aatgtcccaa acattttcaa gagacactga tatgtggaaa agacatttct      360

tctggatatc cgccagatat tcctgatgaa gtaacctgtg tcatttatga atattcaggc      420

aacatgactt gcacctggaa tgctgggaag ctcacctaca tagacacaaa atacgtggta      480

catgtgaaga gtttagagac agaagaagag caacagtatc tcacctcaag ctatattaac      540

atctccactg attcattaca aggtggcaag aagtacttgg tttgggtcca agcagcaaac      600

gcactaggca tggaagagtc aaaacaactg caaattcacc tggatgatat agtgatacct      660

tctgcagccg tcatttccag ggctgagact ataaatgcta cagtgcccaa gaccataatt      720

tattgggata gtcaaacaac aattgaaaag gtttcctgtg aaatgagata caaggctaca      780

acaaaccaaa cttggaatgt taaagaattt gacaccaatt ttacatatgt gcaacagtca      840

gaattctact tggagccaaa cattaagtac gtatttcaag tgagatgtca agaaacaggc      900

aaaaggtact ggcagccttg gagttcaccg ttttttcata aaacacctga aacagttccc      960

caggtcacat caaaagcatt ccaacatgac acatggaatt ctgggctaac agttgcttcc     1020

atctctacag ggcaccttac cggtggaggt ggaggtggag gtggaggtca gccccgagaa     1080

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1200

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1260

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1320

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1380

ggtaaatag                                                             1389


<210>  6
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct sIL23R-9gly-CH3

<400>  6

Met Asn His Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Pro Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Gly Gly Gly Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  7
<211>  1302
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct sIL17RA-9gly-CH3

<400>  7
atgggggccg cacgcagccc gccgtccgct gtcccggggc ccctgctggg gctgctcctg       60

ctgctcctgg gcgtgctggc cccgggtggc gcctccctgc gactcctgga ccaccgggcg      120

ctggtctgct cccagccggg gctaaactgc acggtcaaga atagtacctg cctggatgac      180

agctggattc accctcgaaa cctgaccccc tcctccccaa aggacctgca gatccagctg      240

cactttgccc acacccaaca aggagacctg ttccccgtgg ctcacatcga atggacactg      300

cagacagacg ccagcatcct gtacctcgag ggtgcagagt tatctgtcct gcagctgaac      360

accaatgaac gtttgtgcgt caggtttgag tttctgtcca aactgaggca tcaccacagg      420

cggtggcgtt ttaccttcag ccactttgtg gttgaccctg accaggaata tgaggtgacc      480

gttcaccacc tgcccaagcc catccctgat ggggacccaa accaccagtc caagaatttc      540

cttgtgcctg actgtgagca cgccaggatg aaggtaacca cgccatgcat gagctcaggc      600

agcctgtggg accccaacat caccgtggag accctggagg cccaccagct gcgtgtgagc      660

ttcaccctgt ggaacgaatc tacccattac cagatcctgc tgaccagttt tccgcacatg      720

gagaaccaca gttgctttga gcacatgcac cacatacctg cgcccagacc agaagagttc      780

caccagcgat ccaacgtcac actcactcta cgcaacctta aagggtgctg tcgccaccaa      840

gtgcagatcc agcccttctt cagcagctgc ctcaatgact gcctcagaca ctccgcgact      900

gtttcctgcc cagaaatgcc agacactcca gaaccaattc cggactacat gaccggtgga      960

ggtggaggtg gaggtggagg tcagccccga gaaccacagg tgtacaccct gcccccatcc     1020

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1080

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1140

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1200

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1260

cactacacgc agaagagcct ctccctgtct ccgggtaaat ag                        1302


<210>  8
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct sIL17RA-9gly-CH3

<400>  8

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Thr Gly Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430         


Lys 
    


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  9

Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  10

Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  11

Ser Ser Ser Ser Ser Ser Ser Ser Ser 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  12

Gly Gly Gly Gly Gly Cys Pro Pro Cys 
1               5                   


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  14

Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
1               5                   10              


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  15

Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
1               5                   10                  


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  16

Gly Asp Leu Ile Tyr Arg Asn Gln Lys 
1               5                   


<210>  17
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  17

Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro Ser Cys Val Pro Leu Met 
1               5                   10                  15      


Arg Cys Gly Gly Cys Cys Asn 
            20              





